[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].
Identifieur interne : 000E80 ( France/Analysis ); précédent : 000E79; suivant : 000E81[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].
Auteurs : C. Lacroix [France] ; M. Peureux ; M. Borel ; J. GoulleSource :
- Acta clinica Belgica [ 1784-3286 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Anesthetics, Local, Lidocaine.
- chemical , adverse effects : Anesthetics, Local, Lidocaine.
- chemically induced : Methemoglobinemia.
- Adult, Humans, Male, Substance-Related Disorders.
Abstract
Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1% following repeated Xylocaine gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.
PubMed: 11974447
Affiliations:
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pubmed:11974447Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].</title><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre, France. clacroix@ch-havre.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre</wicri:regionArea></affiliation></author><author><name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name></author><author><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name></author><author><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:11974447</idno><idno type="pmid">11974447</idno><idno type="wicri:Area/PubMed/Corpus">000364</idno><idno type="wicri:Area/PubMed/Curation">000364</idno><idno type="wicri:Area/PubMed/Checkpoint">000364</idno><idno type="wicri:Area/Ncbi/Merge">000048</idno><idno type="wicri:Area/Ncbi/Curation">000048</idno><idno type="wicri:Area/Ncbi/Checkpoint">000048</idno><idno type="wicri:doubleKey">1784-3286:2002:Lacroix C:methemoglobinemia:induced:by</idno><idno type="wicri:Area/Main/Merge">001595</idno><idno type="wicri:Area/Main/Curation">001554</idno><idno type="wicri:Area/Main/Exploration">001554</idno><idno type="wicri:Area/France/Extraction">000E80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Methemoglobinemia induced by repeated abuse of lidocaine viscous gel].</title><author><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre, France. clacroix@ch-havre.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacocinétique et de Toxicologie Clinique-Groupe Hospitalier B.P. 24-76083 Le Havre</wicri:regionArea></affiliation></author><author><name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name></author><author><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name></author><author><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name></author></analytic><series><title level="j">Acta clinica Belgica</title><idno type="ISSN">1784-3286</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anesthetics, Local (administration & dosage)</term><term>Anesthetics, Local (adverse effects)</term><term>Humans</term><term>Lidocaine (administration & dosage)</term><term>Lidocaine (adverse effects)</term><term>Male</term><term>Methemoglobinemia (chemically induced)</term><term>Substance-Related Disorders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anesthetics, Local</term><term>Lidocaine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anesthetics, Local</term><term>Lidocaine</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Methemoglobinemia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Male</term><term>Substance-Related Disorders</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lidocaine use may lead to methemoglobinemia. Lidocaine is clinically widely used as an anaesthesic drug, however its toxic effect is rare. We report a high methemoglobinemia level of 31.1% following repeated Xylocaine gel oral applications. New metabolic pathways of lidocaine have been reported leading to dimethylphenylhydroxylamine in humans. This metabolism is very similar to the aniline derivative ones, and may explain lidocaine methemoglobinemia effect.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Borel, M" sort="Borel, M" uniqKey="Borel M" first="M" last="Borel">M. Borel</name><name sortKey="Goulle, J" sort="Goulle, J" uniqKey="Goulle J" first="J" last="Goulle">J. Goulle</name><name sortKey="Peureux, M" sort="Peureux, M" uniqKey="Peureux M" first="M" last="Peureux">M. Peureux</name></noCountry><country name="France"><noRegion><name sortKey="Lacroix, C" sort="Lacroix, C" uniqKey="Lacroix C" first="C" last="Lacroix">C. Lacroix</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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